Faculty Members: Hans Othmer
Cell locomotion plays an essential role during embryonic development, angiogenesis, tissue regeneration, the immune response, and wound healing in multicellular organisms. Movement is a very complex process that involves the spatio-temporal control and integration of a number of sub-processes, including the transduction of chemical or mechanical signals from the environment, intracellular biochemical responses, and translation of the intra- and extracellular signals into a mechanical response. Movement entails force generation within cells and mechanical interactions with their surroundings, and understanding how they are controlled in space and time to produce cell-level movement is currently the focus of a large number of labs. This project is focused on models and analysis of sub-processes, with the long-term objective of an integrated model of cell movement.