Current Series

[View Past Series]

Mon Oct 19

Math Biology Seminar

12:00pm - Via Zoom
Mathematical Virology: Geometry as a key to the discovery of novel anti-viral solutions
Reidun Twarock, University of York, UK 

Viruses encapsulate their genetic material into protein containers that act akin to molecular Trojan horses, protecting viral genomes between rounds of infection and facilitating their release into the host cell environment. In the majority of viruses, including major human pathogens, these containers have icosahedral symmetry. Mathematical techniques from group, graph and tiling theory can therefore be used to better understand how viruses form, evolve and infect their hosts, and point the way to novel antiviral solutions. In this talk, I will present a theory of virus architecture, that contains the seminal Caspar Klug theory as a special case and solves long-standing open problems in structural virology. I will also introduce mathematical models of symmetry breaking in viral capsids and discuss their consequences for our understanding of more complex viral geometries. By combining these geometric insights with a range of different mathematical and computational modelling techniques, I will demonstrate how viral life cycles can be better understood through the lens of viral geometry, and how such insights can act as drivers of discovery of novel anti-viral solutions. Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Oct 26

Math Biology Seminar

12:00pm - Zoom Details see abstract
Math Biology Seminar
Pei Liu, University of Minnesota

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Nov 02

Math Biology Seminar

12:00pm - Zoom Details see abstract
Math Biology Seminar
Mariel Vazquez, University of California Davis

Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Nov 09

Math Biology Seminar

12:00pm - Via Zoom
Math Biology Seminar
Sharon Lubkin, North Carolina State University

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Nov 16

Math Biology Seminar

12:00pm - Via Zoom
Math Biology Seminar
Alain Goriely, Oxford

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Nov 23

Math Biology Seminar

12:00pm - Via Zoom
Math Biology Seminar
Jody Reimer, University of Utah

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Nov 30

Math Biology Seminar

12:00pm - Via Zoom
Math Biology Seminar
Zoi Rapti, University of Illinois

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Dec 07

Math Biology Seminar

12:00pm - Via Zoom
Mathematical model of colorectal cancer initiation
Ivana Bozic, University of Washington

 Cancer evolution cannot be observed directly in patients, and new methodologies are needed for obtaining a quantitative understanding of this obscure process. We developed and analyzed a stochastic model of malignant transformation in the colon that precisely quantifies the process of colorectal carcinogenesis in patients through loss of tumor suppressors APC and TP53 and gain of the KRAS oncogene. Our study employs experimentally measured mutation rates in the colon and growth advantages provided by driver mutations. We calculate the probability of a colorectal malignancy, the sizes of premalignant lesions, and the order of acquisition of driver mutations during colorectal tumor evolution. We demonstrate that the order of driver events in colorectal cancer is determined primarily by the fitness effects that they provide, rather than their mutation rates. Link to Paper.Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Dec 14

Math Biology Seminar

12:00pm - Via Zoom
Math Biology Seminar
Philip Maini, Oxford

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8

Mon Dec 21

Math Biology Seminar

12:00pm - Via Zoom
Math Biology Seminar
Jana Gevertz, The College of New Jersey

Zoom details:Join Zoom Meeting https://umn.zoom.us/j/94817303643?pwd=aHBrNFpzaFdLSU9HUjJybllla3M3QT09 Meeting ID: 948 1730 3643 Passcode: R90eZ8